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Nemvaleukin alfa
CAS No. 2315268-27-8
Nemvaleukin alfa( —— )
Catalog No. M36815 CAS No. 2315268-27-8
Nemvaleukin alfa (ALKS 4230) is an interleukin 2 fusion protein, a selective agonist of the medium-affinity IL-2 receptor, produced by fusion of the IL-2Ralpha subunit of the circularly arranged interleukin-2 (IL-2) and IL-2 receptor (IL-2R) complexes, which drives antitumor Immunity and inhibits tumor growth in small cell lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 628 | Get Quote |
|
| 5MG | 1017 | Get Quote |
|
| 10MG | 1634 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNemvaleukin alfa
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NoteResearch use only, not for human use.
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Brief DescriptionNemvaleukin alfa (ALKS 4230) is an interleukin 2 fusion protein, a selective agonist of the medium-affinity IL-2 receptor, produced by fusion of the IL-2Ralpha subunit of the circularly arranged interleukin-2 (IL-2) and IL-2 receptor (IL-2R) complexes, which drives antitumor Immunity and inhibits tumor growth in small cell lung cancer.
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DescriptionNemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer.
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In Vitro——
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In VivoAnimal Model:SCLC orthotopic model Dosage:6 mg/kg Administration:s.c., every 4?days Result:Delayed tumor growth and prolonged survival. Animal Model:Male cynomolgus monkeys (PK Assay) Dosage:0.3 or 1 mg/kg Administration:i.v. or s.c.Result:Pharmacokinetic profile of Nemvaleukin alfa.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorInterleukin
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Research Area——
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Indication——
Chemical Information
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CAS Number2315268-27-8
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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L-allo-Threonine
Threonine is an essential amino acid in humans. It is abundant in human plasma particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function.
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Orexin A (human, rat...
Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
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Butyrospermol
Butyrospermol is a protolimonoid extracted from shea (Euphorbia). As a long-chain fatty acid ester first discovered from natural products, Butyrospermol has antifeedant and antitumor activities.
